Cov tshuaj tsuag tshiab siv ntau txhiab tus tub rog me los tua cov zaub mov

Los ntawm romaine lettuce rau khov falafel, US Food and Drug Administration (FDA) cov npe rov qab tau sau txhua xyoo nrog cov khoom uas muaj kab mob. Escherichia coli (E. coli) uas ua rau muaj ntau yam kab mob ntawm cov zaub mov. E. coli yog tus kab mob culprit tom qab lub khwv yees 265,000 tus kab mob txhua xyoo Hauv Tebchaws Meskas, raws li Lub Chaw Tiv Thaiv Kab Mob thiab Tiv Thaiv (CDC). Tam sim no, cov tshuaj tsuag uas cov kws tshawb fawb piav txog ntau lab tus tub rog me me muaj txoj hauv kev tshiab los tua cov zaub mov thiab txo cov kab mob.

Ntawm McMaster University, tus xibfwb Zeinab Hosseinidoust, tus xibfwb Tohid Didar thiab cov tub ntxhais kawm tiav Lei Tian tau tsim ib txoj hauv kev los tawm tsam cov kab mob hauv cov zaub mov los ntawm kev siv cov kab mob bacteriophages. Tus kab mob bacteriophage, tseem hu ua phage, yog ib hom kab mob uas tsis tuaj yeem kis rau tib neeg lub hlwb. Txawm li cas los xij, lub npe bacteriophage qhia nws lub hom phiaj tseem ceeb: Nws yog cov kab mob noj uas tuaj yeem kis tau thiab rhuav tshem cov kab mob.

Hauv lawv daim ntawv, luam tawm nyob rau hauv Xov Xwm Kev Sib Txuas Lus, cov kws tshawb fawb piav txog kev sib txuas cov kab mob bacteriophages ua ke los tsim cov hlaws me me, nrog txhua cov hlaws ntev txog 20 microns hauv txoj kab uas hla. Rau kev sib piv, tib neeg cov plaub hau yog li 70 microns inch. Tag nrho ua ke, lawv txuas ib nrab ntawm ib lab bacteriophages los ua txhua cov hlaws thiab tsim ib lub zej zog ntawm 13 billion bacteriophages.

Thaum sib sau ua ke, cov kab mob bacteriophages tau muab txau rau ntawm romaine lettuce thiab nqaij nyug steaks kis nrog. E. coli O157:H7, ib hom kab mob uas ua rau mob hnyav kab mob plab hnyuv thiab feem ntau kis rau lettuce thiab nqaij. Tom qab ntawd, cov tub rog ntawm cov tub rog bacteriophage me me tau mus ua haujlwm.

Cov kws tshawb fawb tau tshaj tawm cov txiaj ntsig los ntawm kev sib faib cov cav txo qis, uas qhia tau hais tias cov tshuaj tsuag zoo li cas hauv kev tua cov kab mob. Cov tshuaj bacteriophage txo qis E. coli O157: H7 los ntawm 6 lub log lossis 99.9999%.

Ntxiv rau qhov ua tau zoo, cov tshuaj bacteriophage muaj kev nyab xeeb siv rau ntawm cov khoom noj thiab tsis hloov cov saj, kev ntxhib los mos lossis zoo ntawm cov zaub mov. Ntxiv mus, bacteriophages yog qhov tshwj xeeb thiab tsuas yog ua mob rau cov kab mob hauv lub hom phiaj thaum tso cov kab mob muaj txiaj ntsig ib leeg.

Cov tshuaj tiv thaiv kab mob tiv thaiv tau nce ntxiv, tab sis cov tshuaj tua kab mob bacteriophage qhia cov lus cog tseg thiab muaj peev xwm ua kom tiav qhov khoob uas cov tshuaj tua kab mob tsim tsis zoo. Nws yog ib qho tseem ceeb kom nco ntsoov tias txij li thaum 1958 FDA tau lees paub bacteriophages thiab lawv cov derivatives li GRAS (feem ntau lees paub tias muaj kev nyab xeeb). Bacteriophages twb tau siv rau hauv cov khoom xws li tsiaj pub rau tsiaj noj.

Cov kws tshawb fawb pom muaj ntau yam siv tau rau cov tshuaj bacteriophage. Ua ntej, nws tuaj yeem hloov kho kom rhuav tshem lwm hom kab mob, suav nrog Salmonella thiab Listeria, uas nquag paug cov zaub mov. Thib ob, nws tuaj yeem siv rau hauv cov ntawv thov kev lag luam rau kev sau zaub mov, ua thiab ntim khoom. Thib peb, cov khw muag khoom noj tuaj yeem txau cov khoom ntawm cov txee nrog cov kab mob bacteriophages ntxiv rau dej. Plaub, bacteriophages tuaj yeem muab ntxiv rau cov khoom siv tshuaj tua kab mob hauv tsev uas tuaj yeem tshem tawm txhua yam los ntawm cov zaub tshiab rau txiv hmab txiv ntoo.

Nrhiav txoj hauv kev tshiab kom tshem tawm cov zaub mov yog qhov tseem ceeb rau kev tiv thaiv kab mob. Lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv (WHO) kwv yees 600 lab cov neeg mob tom qab noj zaub mov tsis huv, thiab 420,000 tus neeg tuag txhua xyoo. Cov menyuam yaus hnub nyoog qis dua tsib xyoos suav txog yuav luag ib feem peb ntawm tag nrho cov mob, nrog 125,000 tuag txhua xyoo. Bacteriophages muaj peev xwm txo tau cov kab mob kis thoob ntiaj teb thiab cawm neeg txoj sia.