Lub Tuam Txhab Microbial Immunotherapy Prokarium nce $ 30M Ntawm Heels Ntawm Ginkgo Bioworks Partnership

Thaum ib tug hnov ​​lo lus Salmonella, kev koom tes tam sim no tej zaum yuav ua rau cov zaub mov lom, lossis txawm tias qe; rau Koob tshuaj BCG, tus khub feem ntau yuav yog tuberculosis. Cov couplings no yog qee qhov kev sib txuas ntawm cov kab mob etiology thiab kev kho mob hauv keeb kwm biomedical, tab sis txawm tias cov kev sib txuas no tsis yog txhua yam uas lawv yuav zoo li nyob rau saum npoo - thiab London-based biopharma tuam txhab Prokarium tau npaj los tawm tsam cov kev sib txawv no nrog rau qhov tsis ntev los no. tshaj tawm ntawm lawv $30 lab nyiaj txiag puag ncig coj los ntawm Flerie Invest, tshiab tshaj tawm tshaj tawm ntawm kev koom tes tshiab nrog Ginkgo Bioworks.

Nrog nws cov evolutionarily optimized Salmonella strain chassis, Prokarium tus flagship "nyob tshuaj" kab mob raws li immunotherapy kev pab cuam lub hom phiaj mus rau pem hauv ntej nyob rau hauv kev sib ntaus tawm tsam lub zais zis cancer - uas BCG yog tam sim no tus qauv-kev saib xyuas. Thaum lub tuam txhab tab tom nrhiav kev kho mob hauv nws thawj tus neeg mob xyoo no, "qhov tseeb txhawb pab pawg ntawm Prokarium yog peb lub hom phiaj los tsim cov kab mob zoo tshaj plaws los tsim cov kev kho mob nyob rau kev kho mob qog noj ntshav," said CEO Kristen Albright. "Taming tus kab mob thiab siv ntau lab xyoo ntawm kev hloov pauv los coj txoj hauv kev rau tiam tshiab ntawm kev kho mob oncology yog lub tswv yim zoo, tsis muaj ntau lub tuam txhab biotech ua haujlwm."

Qhov no microbial immunotherapy system tsim los ntawm engineered strain ntawm Salmonella sawv rau tshwj xeeb tshaj yog pab tau rau cov neeg mob uas muaj mob qog noj ntshav nrog nws lub peev xwm mus lyse qog nqaij hlav cancer, tiv thaiv qog microenvironments, bolster anti-tumor host lub cev tiv thaiv teb, thiab xa ntau yam kev kho mob payloads nyob rau hauv daim ntawv. ntawm kev cai synthetic circuits - raws li cov ingrained qog-colonizing nta ntawm lub cev. Ntau tshaj 500,000 tus neeg mob tau kuaj pom thoob ntiaj teb hauv ib xyoos; Nws feem ntau tshwm sim nyob rau hauv daim ntawv uas tsis yog-muscle invasive thiab kuaj pom thaum ntxov, tab sis txawm tias kev kho mob nrog BCG ntau tus neeg mob yuav muaj kab mob rov qab. Txawm li cas los xij, Prokarium platform aims los tsim ib tiam tshiab ntawm immunotherapies rau tej yam mob tshaj lub zais zis mob cancer, raws li muaj ntau yam immunotherapies ua tsis tau tejyam tiv thaiv lub cev tsis ua hauj lwm muaj feem xyuam rau cov kab mob cancer thiab ib tug loj cov neeg mob sawv los tau txais txiaj ntsim los ntawm countering qhov teeb meem no. Cov kab mob Salmonella kuj tau npaj los siv los ua tus neeg saib xyuas kev tiv thaiv qhov ncauj kom rov qab tau ntau yam ntawm tus neeg mob lub cev tiv thaiv kab mob los tiv thaiv qog loj hlob thoob plaws hom qog noj ntshav.

Thaum Prokarium cov kab mob kab mob sib cais thiab muaj zog los ntawm keeb kwm yav dhau los ntawm kev tshawb fawb tshuaj tiv thaiv, Albright tau ua haujlwm ua CEO txij li xyoo 2021 los sib sau ua ke cov pab pawg muaj peev xwm ua kom lub tuam txhab hloov mus rau hauv oncology, uas yuav yog ib qho tseem ceeb rau lub tuam txhab ua tib zoo. taw qhia ntau yam teeb meem cuam tshuam nrog microbial immunotherapy. "Bacteria-based immunotherapy pib nrog Coley cov tshuaj lom ntau tshaj ib puas xyoo dhau los," nws piav qhia. "Txawm li cas los xij, kev nce qib tau cuam tshuam los ntawm kev nkag siab tsawg ntawm kev tiv thaiv kab mob thiab tsis muaj DNA engineering technology. Niaj hnub no, nrog kev paub thiab cov cuab yeej txhim kho, qhov kev sib tw yog hloov kev nkag siab ntawm cov kab mob nyob ua ib qho kev xaiv kho mob qog noj ntshav. "

Cov ntsiab lus tseem ceeb ntawm txoj kev taug mus tom ntej no sawv hauv qhov kev daws teeb meem tawm tsam ntau yam toxicity thiab lub hom phiaj cov teeb meem qee zaum ntsib los ntawm tus kab mob xa mus rau cov kab ke kho noob zoo sib xws. Tau txais kev pab tshwj xeeb los ntawm qhov kev pab nyiaj no thiab lub tuam txhab kev koom tes tshiab nrog cell programming powerhouse Ginkgo Bioworks, tshaj tawm Lub Ib Hlis 9, 2023. Prokarium lub hom phiaj los siv cov khoom siv ntawm bactofection - "kis" cov kab mob mammalian nrog cov caj ces payload, hauv qhov piv txwv no RNA, los ntawm cov kab mob xws li Salmonella. "Peb kev koom tes nrog Ginkgo Bioworks qhib lub qhov rooj rau lawv qhov Foundry thiab dav Codebase [thiab tso cai rau peb] siv cov khoom siv hluav taws xob zoo tshaj plaws los rov tsim peb cov kab mob uas muaj tswv," piav qhia Albright, raws li ob lub tuam txhab nrhiav kom ua qhov bactofection platform no muaj tseeb hauv kev nrhiav. evolution-enabled, tom ntej-tiam kho mob qog noj ntshav.

Hauv lwm lo lus, lwm zaus koj xav Salmonella, xav Prokarium. Cov kab mob no tuaj yeem ua rau muaj zaub mov lom hauv ib daim ntawv, tab sis tsim txoj hauv kev zoo tuaj yeem dhau los ua cov tshuaj muaj sia - tig tsis tau roj rau hauv hluav taws tab sis hluav taws kub.

Ua tsaug rau Aishani Aatresh rau kev tshawb fawb ntxiv thiab qhia txog kab lus no. Kuv yog tus tsim ntawm SynBioBeta thiab qee lub tuam txhab uas kuv sau txog, suav nrog Ginkgo Bioworks, yog tus txhawb nqa ntawm Rooj sablaj SynBioBeta thiab limtiam zom.