Inscripta Yog Reimagining Yuav Ua Li Cas Lub Tuam Txhab Synthetic Biology Ntawm Lub Neej Tom Ntej Yuav Ua

Inscripta, tus thawj coj thoob ntiaj teb hauv genome engineering, tab tom hloov kho cov duab ntawm lub tuam txhab hluavtaws biology.

Biomanufacturing tau teeb tsa los hloov ntau qhov kev lag luam los ntawm kev ua cov khoom lag luam uas lub ntiaj teb xav tau hauv kev huv, zoo dua, thiab kev ruaj ntseg. Tab sis tsis muaj ib phau ntawv ua si yuav ua li cas kom paub txog qhov pom. Raws li kev lag luam hluavtaws biology txuas ntxiv ntsuas cov tswv yim sib txawv rau kev ua tiav thiab kev ua haujlwm ntev, Inscripta tau hloov nws lub zeem muag los ntawm kev ua tus muab kev pabcuam thev naus laus zis los tsim thiab ua lag luam bio-raws li cov khoom siv ntshiv thiab siv tau zoo rau biomanufacturing.

Sri Kosaraju, Inscripta tus thawj tswj hwm thiab CEO, uas yuav los hais lus ntawm SynBioBeta 2023 lub rooj sib tham tshwm sim lub Tsib Hlis no, tau qhia nws cov kev xav txog qhov kev cia siab ntawm hluavtaws biology thiab biomanufacturing:

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Kosaraju tau hais tias "Muaj kev ntseeg siab zuj zus hauv kev ua lag luam muaj peev xwm thiab lub sijhawm ua lag luam thoob plaws ntau qhov sib txawv," said Kosaraju. Thiab Inscripta npaj txhij los coj mus rau hauv qhov kev lag luam muaj peev xwm. Lub lim tiam dhau los, lub tuam txhab tshaj tawm qhov tau txais ntawm Sestina Bio thiab Infinome Biosciences hauv kev ua siab tawv uas ua rau muaj kev hloov pauv hauv kev coj ua. Muaj kiag li kev rov tsim dua nws txoj kev lag luam, lub tuam txhab tau npaj rau tshooj tshiab.

Los ntawm kev muag khoom thiab shovels mus rau mining kub

Inscripta yog ib qho ntawm cov pioneers hauv kev tsim cov cuab yeej engineering microbes los tsim cov tshuaj, enzymes, cov ntaub ntawv, thiab lwm yam khoom siv bio-based. Lawv cov thev naus laus zis yog raws li CRISPR genome kho, qhov kev tshawb pom tseem ceeb uas tau txais txiaj ntsig ntawm chemistry Nobel nqi zog Xyoo 2020. Lub tuam txhab tau tsim lub CRISPR-raws li platform rau high-throughput editing ntawm microbes uas yuav siv tau rau suav tsis tau cov khoom siv hluavtaws biology, los ntawm kev ua cov khoom xyaw ruaj khov rau kev tsim tshiab. tshuaj tua kab mob. Nws muaj peev xwm cuam tshuam yog kev hloov pauv: tib txoj hauv kev txuas ntxiv tom ntej (NGS) hloov pauv kev nyeem DNA, Inscripta thev naus laus zis hloov pauv kev sau DNA.

Tab sis Inscripta tab tom tso tawm cov qauv kev lag luam xaiv-thiab-shovels thiab tsom mus rau kev khawb cov kub - txav mus rau cov saw muaj nqis kom tsom mus rau kev tsim cov khoom siv bio-based tshiab. Ua li ntawd, lawv tab tom nqa cov thev naus laus zis zoo tshaj plaws thiab kev txawj ntse kom nrawm biomanufacturing innovation. Tom qab tsim cov thev naus laus zis, lub tuam txhab tam sim no muaj peev xwm ua tau zoo nrog kev nrhiav tau ntawm Sestina Bio thiab Infinome Biosciences thiab nrhiav seb yuav ua li cas rau engineering biology hauv txoj kev ceev tshaj plaws thiab muaj txiaj ntsig zoo tshaj plaws los nqis peev rau biomanufacturing kub maj.

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Npau suav Team

Inscripta tau nyob rau ntawm qhov chaw txij li xyoo 2017. Lub Colorado startup tau dhau los ntawm kev nthuav dav sai thaum nws tab tom tsim tawm nws cov genome engineering platform thiab tau nce ze li ib nrab lab nyiaj hauv tag nrho cov nyiaj los ntawm qhov kawg ntawm 2021. Tab sis qhov kev loj hlob tau ua pov thawj tsis ruaj khov thiab Inscripta xaus. nce downsizing tseem ceeb hauv lub lub quarter kawg ntawm 2022. Nrog rau qhov kev txav no, lawv nyuaj rau kev lag luam kev lag luam nrov brute-force mus kom ze los tsim cov khoom lag luam bio-based thiab es tsis txhob xav txog ntau dua ntawm "lub tuam txhab lean" qauv.

Tig lub tswv yim hluavtaws biology rau hauv ib yam khoom muaj ob qhov tseem ceeb. Txoj haujlwm saum toj kawg nkaus yog rov sau cov DNA code rau kev pab cuam microbes los ua ib yam khoom tshwj xeeb. Cov theem qis-up thiab cov txheej txheem optimization theem koom nrog optimizing DNA code los pab ua cov khoom ntawm kev lag luam nplai. Inscripta qhov kev yuav khoom tsis ntev los no coj los ntawm cov kev paub ntxiv thiab kev txawj ntse ua ke. Nrog ob tus neeg siv khoom qub tam sim no yog ib feem ntawm lub tuam txhab, Inscripta tau sib sau ua ke ib pab pawg npau suav ntawm cov khoom siv hluav taws xob zoo nkauj tshaj plaws.

Infinome yog ib tug spinout los ntawm Inscripta, nrhiav tau los ntawm ib tug ntawm cov thawj coj xav nyob rau hauv lub teb, Richard Fox, thiab ib tug ntawm Inscripta tus tsim, Andrew Garst. Infinome's co-founders yog qee tus thawj coj kom paub txog lub zog ntawm Inscripta's technology. Lawv xav pom dab tsi lawv tuaj yeem ua tiav nrog cov cuab yeej siv hluav taws xob muaj zog genome thiab pab pawg me ntawm cov kws tshaj lij uas nkag siab txog cov ntsiab lus tseem ceeb thiab cov teeb meem ntawm engineering biology:

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Fox, uas tam sim no yog Senior VP ntawm Synthetic Biology Products ntawm Inscripta hais tias "Kev tswj cov genomes kom txog thaum nyuam qhuav tau qeeb heev, ua haujlwm hnyav, thiab kim," hais. "Peb tuaj yeem ua nws sai dua li yav dhau los."

Nrog nce kev sib tw hauv kev tsim thiab kev lag luam bio-raws li cov khoom lag luam, muaj peev xwm tsim cov kab mob sai dua muab kev sib tw loj. Infinome tab tom nqa qhov kev txawj ntse nrog rau "ntse" lub tswv yim ntawm lub tuam txhab hluav taws xob biology li cas yuav tsum yog. Lawv Lean Bioengineering ™ txoj hauv kev los ua biomanufacturing scalable thiab nqi-zoo ua ke nrog qhov zoo tshaj plaws ntawm cov technologies uas twb muaj lawm, xws li Directed Evolution, CRISPR, thiab Machine Learning.

Sestina Bio muaj tib lub tswv yim, nrog rau lub hom phiaj ntawm kev tsim cov kev lag luam zoo tshaj plaws ntawm ib feem ntawm lub sijhawm thiab tus nqi. Kev pib ua haujlwm hauv Bay Area tau tsim muaj nyob rau xyoo 2020 thiab tau qhia txog kev ua tau zoo ntawm lawv txoj hauv kev tawm ntawm lub rooj vag, txawm tias muaj kev sib tw ntawm kev ua haujlwm thaum muaj kev sib kis. Lub tuam txhab tau tshaj tawm nws thawj qhov kev vam meej nyob rau lub Kaum Hli xyoo tas los, tshaj tawm txoj kev loj hlob ntawm cov txheej txheem-up-npaj strain uas tsim cov khoom xyaw tseem ceeb, bakuchiol, hauv tsawg dua 12 hli nrog kev pab los ntawm Inscripta lub ntsiab technology. Rau ib lub tuam txhab hluavtaws biology, tsis hais qhov loj me, qhov no yog lub sijhawm kev loj hlob tsis tau pom dua, thiab Sestina thaum lub sijhawm ua haujlwm nrog pab pawg ze rau kaum tus neeg.

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Sestina qhov kev txawj ntse hauv kev tsim cov kab mob uas tuaj yeem tiv taus qhov nruj ntawm kev lag luam kev lag luam yog nyob ntawm kev sib koom ua ke cov ntaub ntawv siab thiab kev kwv yees ua qauv rau hauv lawv cov txheej txheem kev loj hlob, uas tuaj yeem txuag lub hlis thaum lub sij hawm nce qib. Qhov no yog ib qho piv txwv zoo ntawm yuav ua li cas kev sib xyaw ntawm cov cuab yeej ntub dej hauv chav kuaj thiab kev suav lub zog tuaj yeem ua rau kev npau suav ntawm hluavtaws biology yav tom ntej rau lub neej, qhov twg txhua yam yog tsim los ntawm biology los ntawm cov khaub ncaws peb hnav. cov khoom kom hniav zoo nkauj peb muab tso rau ntawm peb daim tawv nqaij. Bakuchiol yog ib qho ntawm cov khoom xyaw ntuj hero uas muaj cov txiaj ntsig zoo ntawm daim tawv nqaij, zoo ib yam li cov retinol, tab sis tsis muaj kev phiv xws li khaus thiab UV rhiab heev. Tab sis bakuchiol tam sim no tau muab rho tawm los ntawm cov nroj tsuag uas raug hem, nthuav qhia qhov cuam tshuam rau nws txoj kev saws me nyuam raws li cov khoom siv tshuaj pleev ib ce dav siv. Ua tib yam molecule hauv cov poov xab es tsis txhob rho tawm los ntawm cov nroj tsuag, tuaj yeem daws qhov teeb meem no.

Ib tug tshiab hluavtaws biology tuam txhab qauv

Qhov kev vam meej bakuchiol yog ib qho piv txwv zoo ntawm qhov ua tau zoo nrog txoj hauv kev zoo rau genome engineering uas Inscripta tau pioneered ua ke nrog ib pab neeg ntawm cov kws tshaj lij. Sestina thiab Infinome muab cov txheej txheem ntawm kev txawj ntse tsim nyog los hloov cov tswv yim rau hauv cov khoom lag luam-npaj: "Peb txoj hauv kev mesh ua ke zoo heev. Tsis muaj qhov sib ntxiv lossis sib tshooj hauv kuv lub siab, "hais tias Andrew Horwitz, yav dhau los VP ntawm R&D ntawm Sestina Bio thiab tam sim no ntawm Inscripta.

Thiab muaj ntau ntau cov haujlwm uas tau siav rau kev tsim kho tshiab: "Muaj ntau lub tuam txhab uas twb tau cog lus rau kev ruaj khov thiab rau qee qhov kev pib, tab sis lawv muaj lub sijhawm nyuaj heev los txiav txim siab ua qhov no," Kosaraju taw qhia. . "Thiab kuv xav tias yog lub sijhawm rau peb los koom nrog cov neeg ntawd."

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"Thaum [synthetic biology] cov tuam txhab thov nyiaj ntau lab thiab xyoo ntawm kev txhim kho, qhov no tsis yog pib rau ntau lub tuam txhab uas tab tom sim nkag mus rau hauv qhov chaw no," vib nas this Fox. "Peb ua kom yooj yim dua kom nkag mus rau hauv synbio thiab nqis peev ntawm lub sijhawm."

Dab tsi ua rau nws ua tau yog kev sib xyaw ua ke ntawm lean-lub tuam txhab mus kom ze thiab cov thev naus laus zis zoo tshaj plaws hauv kev ua haujlwm. Feem ntau cov tuam txhab ntawm qhov loj me no tsom mus rau kev tsim ib yam khoom, thiab kev ua tiav ntawm cov khoom ntawd yog qhov muaj nyob. Tab sis Inscripta muaj peev xwm tsim tau cov khoom lag luam tag nrho, piv rau cov biofoundry loj uas muaj ntau lab nyiaj tau nqis peev rau hauv kev tsim kho vaj tse, nrog ntau cov peev txheej tsawg:

"Feem ntau cov tuam txhab synbio ua haujlwm nrog pab pawg ntawm ntau tus neeg lossis ntau dua. Peb muaj pab pawg ntawm peb mus rau tsib tus neeg. Hloov ntawm lub hlis ntawm lub sijhawm txhim kho, peb tuaj yeem ua lub lis piam. Hloov chaw ua tsib lossis 10 lossis 100 qhov hloov pauv, peb tuaj yeem ua tau 10,000, ”Fox hais. Nws yog ib yam dab tsi tiag tiag uas kev lag luam tsis tau pom ua ntej.

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Ua tsaug rau koj Katia Tarasava rau kev tshawb fawb ntxiv thiab qhia txog kab lus no. Kuv yog tus tsim ntawm SynBioBeta, thiab qee lub tuam txhab uas kuv sau txog, suav nrog Inscripta, yog tus txhawb nqa ntawm Rooj sablaj SynBioBeta thiab limtiam zom.