Ginkgo tau ntiav ib lub taub hau tshiab ntawm Biopharma los cuam tshuam cov noob caj noob ces thiab kev kho mob ntawm tes

Kev kho mob ntawm tes thiab noob caj noob ces yuav yog qhov kev xav tau tshaj plaws ntawm lub xyoo pua no. Rau ntau tus neeg, cov kev tawg no tsis tuaj yeem tuaj sai txaus: kev kho mob ntawm tes tuaj yeem muaj kev cia siab rau cov neeg mob qog noj ntshav sai, kho cov kab mob caj ces xws li mob qog noj ntshav, thiab tseem tuaj yeem kho cov mob xws li mob plawv thiab ntshav qab zib. Txawm li cas los xij, kev nce qib qeeb thiab tus nqi ntawm ib qho kev kho mob tuaj yeem nce mus txog $ 3.5 lab, ua rau lawv nkag tsis tau rau cov neeg mob feem ntau. Kuv tau tham nrog Behzad Mahdavi, tus thawj coj tshiab ntawm Biopharma Manufacturing & Life Sciences Tools ntawm Ginkgo Bioworks, leej twg yuav hais lus ntawm SynBioBeta 2023, Lub Rooj Sib Tham Thoob Ntiaj Teb Synthetic Biology, kom nkag siab tias yuav tsum tau ua dab tsi los ua kom cov kev kho cawm siav no pheej yig dua.

Tus qauv tshuaj pharma tshuaj txhim kho yog ib feem los liam rau tus nqi siab. Kev lag luam tau tswj hwm hnyav, yog li kev siv cov kev hloov pauv yuav siv sij hawm ntev thiab yuav tsum tau nqis peev ntau ua ntej. Kev tsim kho tshiab yuav txuag tau nyiaj nyob rau lub sijhawm ntev, tab sis kev tsim cov thev naus laus zis tshiab cuam tshuam nrog qee qhov kev pheej hmoo, thiab nws nyuaj rau paub tias lawv tuaj yeem muab txiaj ntsig zoo npaum li cas. Qhov no yog vim li cas feem ntau cov tuam txhab tshuaj tsom rau cov txheej txheem thiab kev txhim kho kev ua haujlwm, uas tuaj yeem ua kom muaj txiaj ntsig ntau dua 10-20%. Tab sis ua rau kev kho mob ntawm tes thiab noob caj noob ces kev kho mob pheej yig dua xav tau leap-qav kev nce qib ntawm sab biology kom txo tus nqi los ntawm kev txiav txim siab: "Kev txhim kho ntawm kev tsim khoom tsuas yog tsim cov txiaj ntsig zoo," hais Mahdavi. "Peb yuav tsum rov qab mus rau biology thiab muaj kev nkag siab zoo dua ntawm nws ua haujlwm li cas. Synthetic biology pab peb ua qhov ntawd. "

Ginkgo Bioworks Cov tau ua nws lub npe raws li ib tug hluavtaws biology platform uas pab lawv cov neeg muas zaub tsim bio-raws li cov khoom siv engineered kab mob. Ginkgo tau koom tes nrog tuam txhab uas muag npog ntau yam kev lag luam los ntawm flavors thiab fragrances rau zaub mov colorants, kab lis kev cai cannabinoids, cov khoom siv tawv nqaij, ntaub ntawv, thiab ntau dua. Tab sis lub tuam txhab hluavtaws biology tsis xav txwv nws tus kheej rau cov khoom xyaw. Ginkgo tau nthuav dav lawv lub platform rau hauv qhov chaw biotherapeutics loj, yog li Mahdavi tau teem sijhawm. Mahdavi tuaj rau Ginkgo nrog cov ntaub ntawv zoo tshaj plaws ntawm kev lag luam kev kho tshiab. Tsis ntev los no, nws tau ua tus VP ntawm Ntiaj Teb Qhib Kev Tsim Kho Tshiab ntawm Catalent Pharma Solutions thiab ua ntej uas yog VP ntawm Strategic Innovation ntawm Swiss chaw tsim tshuaj paus Lonza yuav luag 14 xyoo. Tam sim no Mahdavi pom ntau lub peev xwm los hloov pauv kev lag luam los ntawm kev sib yuav ntawm biopharma thiab hluavtaws biology. "Pharma muaj tus qauv tsim - thiab nws zoo ntawm qhov nws ua. Tab sis qhov kev txhim kho tiag tiag yuav tsum tau ua nyob rau sab biology, "said Mahdavi. "Qhov no yuav tsum muaj kev nkag siab zoo ntawm biology thiab ntau dua-throughput txoj kev rau cell engineering."

Ginkgo's platform yog ib qho kev daws teeb meem tag nrho rau kev kho cell engineering. Lawv cov chaw sim ntau zaj dab neeg - hu ua "chaw tsim khoom” - yog Ginkgo cov chaw tsim khoom lom neeg nruab nrog cov neeg hlau thiab cov cuab yeej txiav uas ua kom muaj kev ua haujlwm siab ntawm tes. Qhov no txhais tau hais tias Ginkgo tuaj yeem tshuaj xyuas ntau pua txhiab lub hlwb thiab cov tshuaj molecular los txheeb xyuas cov neeg sib tw tshuaj zoo tshaj plaws uas yog kuj tus nqi-zoo tshaj los tsim nyob rau hauv scale. Piv txwv li, hauv lawv txoj kev koom tes nrog Aldevron, Ginkgo muaj peev xwm ua kom lawv cov zis ntau ntxiv los ntawm ib qho ntawm 10 siv cell engineering thiab kev txhim kho cov txheej txheem lom neeg. "Qhov ntawd txhais tau tias yog tias koj xav tsim ib tsob nroj [rau cov khoom ntawd], koj tuaj yeem tsim cov nroj tsuag uas me dua 10 npaug, tsuas yog muaj kev txhim kho hauv biology," Mahdavi hais.

Ginkgo twb tau pom thawj zaug ua tiav nrog nws lub platform. Thaum lub sijhawm COVID-19 kis thoob qhov txhia chaw, Ginkgo tau tsim cov phiaj xwm kev noj qab haus huv rau pej xeem, Concentric los ntawm Ginkgo, uas muab cov kev pabcuam kuaj mob los pab taug qab cov kab mob hotspots. Nyob rau sab kev tsim tshuaj tiv thaiv, Ginkgo ua haujlwm nrog Moderna txhawm rau nrhiav pom cov txheej txheem zoo rau kev tsim cov tshuaj tiv thaiv mRNA. Tshaj li COVID-19, Ginkgo tsis ntev los no tau tshaj tawm lwm cov biopharma koom tes nrog Optiva, Selecta, thiab Merck, nrog rau kev nrhiav tau ntawm Circularis, tus tswv RNA tshuaj ntsuam xyuas platform.

Lub hom phiaj tseem ceeb ntawm Mahdavi txoj haujlwm yog qhov muaj peev xwm kho tau (thiab muaj txiaj ntsig zoo) ntawm kev kho mob ntawm tes thiab noob. Ib qho ntawm thawj txoj kev kho cell kom tau txais kev pom zoo los ntawm FDA yog CAR T cell kho rau leukemia, lymphoma, thiab myeloma. Nyob rau hauv no txoj kev kho mob, tus neeg mob lub cev tiv thaiv kab mob yog muab los ntawm lawv tus kheej cov ntshav thiab hloov nyob rau hauv lub chaw kuaj mob los ntawm kev ntxiv ib tug receptor uas muaj peev xwm tsom thiab rhuav tshem cov qog nqaij hlav cancer. Qhov no yuav tsum tau ua kom muaj kev hloov pauv caj ces rau cov hlwb nyob, uas tsis yooj yim li. Qhov no yog vim li cas CAR T kev kho mob raug nqi, qhov nruab nrab, nruab nrab ntawm $ 700,000 thiab $ 1 lab, thiab feem ntau ntawm cov nqi niaj hnub no los ntawm kev tsim cov hloov kho CAR T hlwb. Peb tau tuaj ntev hauv peb lub peev xwm los tsim cov hlwb. Txawm li cas los xij, cellular architecture tseem yog lub thawv dub, uas ua rau tsim cov qauv tshiab no nyuaj heev.

Tam sim no tshaj li 1,000 lub xov tooj ntawm tes thiab noob caj noob ces kev sim tshuaj kho mob sau npe nrog ClinicalTrials.gov, tab sis tsuas yog 14 tau pom zoo rau hnub no. Feem ntau ntawm cov kev sim no tseem nyob rau theem 1 lossis 2, uas txhais tau hais tias lawv tseem nyob deb ntawm kev lag luam. Muab qhov ua tiav tsawg npaum li cas ntawm FDA tso cai kav dej yog, cov kev kho mob zoo li no yuav tsis ua rau kev lag luam. Qhov no yog vim li cas kev nqis peev nyob rau theem pib kom pom cov hom phiaj zoo tshaj plaws yog qhov tseem ceeb heev rau kev txhim kho kev kho kom zoo: "Peb tau tsom mus rau kev tsim khoom hauv txoj kev zoo, tab sis tsis tsim cov tshuaj zoo tshaj plaws," hais Mahdavi. Synthetic biology cov cuab yeej thiab workflows yog tsim los tswj cov complexity ntawm biology, ua rau kom muaj kev vam meej thaum nws los txog rau kev tsim kho cell-raws li kev ua haujlwm.

Muaj kev nce qib ntau hauv cov cuab yeej ua haujlwm siab rau kev ua haujlwm biology uas tuaj yeem txo tus nqi thiab ncua sij hawm ntawm kev tsim kho tshiab ntawm tes thiab noob. Ginkgo tau qhia tias lawv tuaj yeem tsim nyob ib puag ncig 10,000 CAR T cell qiv thiab saib seb leej twg yog cov neeg sib tw ua tau zoo tshaj plaws. Piv txwv li, lawv pom ib pawg ntawm cov hlwb uas tiv taus ntau dua rau kev qaug zog thiab tuaj yeem siv los txhim kho. kev kho mob qog nqaij hlav. Kev ua kom zoo dua ntawm cov khoom siv hluav taws xob siab dhau los ua ke nrog bioinformatics tuaj yeem txhim kho tus naj npawb ntawm kev txhaj tshuaj ntawm lub hom phiaj rau txhua lub hom phiaj tshiab: "Kaum xyoo dhau los, hais tias 'Kuv yuav mus saib 10,000 CAR T tsim' yog npau suav. , tab sis hnub no los saib txawm tias 1 lab kev tsim kho tsis yog ib qho teeb meem, "said Mahdavi.

Rau cov tuam txhab biopharma, hom high-throughput scale no nyuaj ua kom tiav yam tsis tau nqis peev ntau rau hauv cov thev naus laus zis tshiab los hloov kho lawv tag nrho R & D infrastructure. Qhov no yog vim li cas kev koom tes nrog cov tuam txhab hluavtaws biology uas muaj cov kws tshaj lij tshwj xeeb hauv cheeb tsam no tuaj yeem nqa nyiaj khaws cia rau biopharma. "Thaum kawg ntawm hnub nws yog hais txog yuav ua li cas koj tau txais cov khoom zoo tshaj plaws thiab kev tsim khoom zoo nyob rau lub sijhawm luv tshaj plaws - thiab qhov no yog qhov Ginkgo coj mus rau biopharma," said Behzad. Nws xav hais tias hluavtaws biology tuaj yeem cuam tshuam kev siv tshuaj biopharma txoj kev loj hlob hauv txoj hauv kev thiab pab coj txoj kev cawm seej rau tib neeg sai dua.

Ua tsaug rau koj Katia Tarasava rau kev tshawb fawb ntxiv thiab qhia txog kab lus no. Kuv yog tus tsim ntawm SynBioBeta, thiab qee lub tuam txhab uas kuv sau txog, suav nrog Ginkgo Bioworks, yog tus txhawb nqa ntawm Rooj sablaj SynBioBeta thiab limtiam zom.