Txhim kho kev kho mob los ntawm kev sib koom tes thoob ntiaj teb hauv kev sim tshuaj: Cancer Moonshot Pathways

Nco tseg: Thawj Tswj Hwm Joe Biden thaum Lub Ob Hlis tau tshaj tawm txoj haujlwm "Cancer Moonshot" uas lub hom phiaj txo tus neeg tuag los ntawm kev mob qog noj ntshav los ntawm 50% hauv 25 xyoo tom ntej. Nov yog ib feem ntawm cov ntawv tshaj tawm nrog cov kws kho mob qog noj ntshav muab cov lus qhia los pab Moonshot ua tiav. Tom ntej no 3^rd Forbes China Healthcare Summit” on August 27 (August 26 ET) will address “New International Directions For A Reignited Moonshot” as its main theme this year. Registration is free. For more information, contact: [email tiv thaiv]. The following post offers written suggestions from Nancy Y. Lee, MD, Lisa M. DeAngelis, MD and Bob T. Li, MD from the Memorial Sloan Kettering Cancer Center (MSK) in New York.

Hauv 2016, tom qab ntawd Tus Lwm Thawj Coj Joe Biden tau pib ua haujlwm Cancer Moonshot nrog lub hom phiaj txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau tiv thaiv kabmob kheesxaws. Raws li qhov tshwm sim, kev tshawb fawb kev kawm, kev lag luam, thiab cov neeg txhawb nqa cov neeg mob tau koom tes nrog lub zog loj thiab kev txaus siab rau lub hom phiaj sib xws.

Xyoo no, Thawj Tswj Hwm Biden tau txuas ntxiv nws txoj kev mob siab rau kev tawm tsam tus kab mob no thiab tab tom nrhiav kom xaus kev mob qog noj ntshav los ntawm kev teeb tsa lub hom phiaj ntawm kev txo cov neeg tuag los ntawm kev mob qog noj ntshav tsawg kawg 50% hauv 25 xyoo tom ntej. Thawj Tswj Hwm kuj tau tshaj tawm qhov xav tau los txhim kho lub neej zoo ntawm cov neeg mob uas muaj mob qog noj ntshav, nqis peev hauv kev tshuaj xyuas thiab tshawb pom ntxov, hais txog qhov tsis sib xws ntawm kev nkag mus rau kev saib xyuas thiab txhim kho kev sib txawv ntawm cov neeg koom hauv kev sim tshuaj - cov kauj ruam tseem ceeb ntawm kev txhais cov kev tshawb fawb tshawb fawb kom txuag tau. nyob.

Txawm li cas los xij, Cancer Moonshot feem ntau yog Tebchaws Meskas cov thawj coj hauv tebchaws nrog kev siv zog tsawg ntawm kev sib koom tes thoob ntiaj teb, txawm hais tias mob qog noj ntshav tseem yog tus neeg tua neeg thoob ntiaj teb uas siv 10 lab lub neej thoob ntiaj teb txhua xyoo nrog kev puas tsuaj rau lawv tsev neeg. Raws li lub ntiaj teb nkag mus rau lub sijhawm muaj kev sib kis thoob ntiaj teb tau cim los ntawm kev hloov pauv thev naus laus zis thiab kev sib txuas, lub luag haujlwm txhawm rau tshem tawm mob qog noj ntshav uas yog qhov ua rau tuag taus tam sim no tau ua tiav hauv lub neej los ntawm kev sib koom tes thoob ntiaj teb ntawm kev sim tshuaj.

Tus kab mob COVID-19 tau nthuav dav thoob ntiaj teb cov kab ke kev noj qab haus huv thiab nthuav tawm qhov tsis muaj txiaj ntsig thiab qhov tsis zoo hauv peb cov qauv ib txwm txwv rau kev saib xyuas mob qog noj ntshav hauv tsev kho mob hauv tib neeg. Kev sim tshuaj kho mob tam sim no tuaj yeem siv cov kev pom zoo rau tej thaj chaw deb thiab telemedicine technologies los txhim kho kev tso npe kawm thiab saib xyuas kev kho mob, ua soj ntsuam kev sim ntau tus neeg mob-centric thiab muaj peev xwm nkag tau ntau dua hauv cov neeg nyob deb nroog thiab cov zej zog tsis tau txais kev pab.

International multiregional soj ntsuam kev sim nthuav tawm ntau haiv neeg ntawm cov neeg tuaj koom thiab tuaj yeem ua kom lub sijhawm ncua mus rau kev pom zoo los ntawm ntau xyoo. Lub Tebchaws Asmeskas Kev Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) pom zoo ntawm thawj KRAS inhibitor sotorasib yog lub sijhawm dej ntws hauv oncology, vim qhov no yog qhov thawj zaug hauv plaub lub xyoos dhau los txij li thaum nrhiav tau ntawm KRAS, feem ntau mutated oncogene nyob rau hauv tib neeg mob qog noj ntshav.

Dab tsi tsis txaus siab yog qhov tseeb tias qhov kev tawg no tau xa mus rau hauv cov ntaub ntawv ceev tsawg dua peb xyoos (piv rau lub sijhawm 10-15 xyoo kev txhim kho tshuaj) thiab tau ua ntau heev thaum lub sijhawm COVID-19 muaj thoob qhov txhia chaw thaum kev sim tshuaj feem ntau raug kaw. . Cov CodeBreaK100 Kev sim tshuaj tau siv cov cuab yeej saib xyuas tej thaj chaw deb thiab kev sib koom tes thoob ntiaj teb ntawm yim lub teb chaws thoob plaws North America, Asia thiab Europe kom pab xa cov tshuaj xa mus rau thaj chaw deb, telemedicine thiab txuas ntxiv cov neeg mob tau txais txiaj ntsig los xa cov kev paub dhau los no. Los ntawm Project Orbis, FDA Oncology Center of Excellence tau coj kev sib koom tes ntawm kev tswj hwm thoob ntiaj teb kev sib raug zoo ntawm tsoomfwv cov koomhaum, sotorasib tau pom zoo sai sai hauv ntau lub tebchaws sab nraud Tebchaws Meskas, suav nrog Canada, Australia, Nyiv, Switzerland thiab UK, yog li ua kom xa khoom sai. ntawm cov tshuaj tshiab thiab cawm txoj sia rau cov neeg mob ntau dua. Tam sim no peb tuaj yeem siv qhov kev ua tiav no los ua tus qauv rau kev sim tshuaj thoob ntiaj teb hauv lub sijhawm tom qab kis thoob qhov txhia chaw, siv thev naus laus zis thiab kev sib koom tes txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau muaj kev sib kis

Kev pom zoo kom nrawm rau txoj kev kho tshiab yuav tsis yog ib txwm koom nrog cov tshuaj tshiab. NRG Oncology HN001 yog theem III thoob ntiaj teb randomized sim rau tus kheej txoj kev kho mob rau locoregionally advanced nasopharyngeal cancer raws li ib tug tshiab ntshav-based biomarker, plasma Epstein-Barr Virus DNA, txwv tsis pub hu ua kua biopsy. Raws li cov qog nqaij hlav nasopharyngeal muaj ntau dua nyob rau yav qab teb Tuam Tshoj thiab cov teb chaws Asia, nws yog ib qho tseem ceeb rau qhib qhov chaw sim hauv thaj av Asia-Pacific. Txawm hais tias qhov kev sim no tau coj los ntawm Asmeskas tau pib thaum lub Tsib Hlis 2014, thawj tus neeg mob nkag los ntawm Asia tsis tshwm sim txog xyoo tom qab. Qhov sib txawv tseem ceeb hauv kev saib xyuas los ntawm ntau lub teb chaws ua rau muaj kev pom zoo qeeb, tsis kam nkag mus rau qhov kev sim mus rau qee cov neeg xav tau kev pab thiab cov neeg mob tseem ceeb tshaj plaws. Lub sijhawm, kev siv zog, thiab tus nqi siv rau kev saib xyuas kev tswj hwm tau txwv tshwj xeeb yog muab qhov tshiab ntawm cov kua biopsy biomarker.

Kos los ntawm cov kev paub dhau los no thiab cov lus qhia uas tau kawm los ntawm COVID-19, peb xav txog qhov xwm txheej tshiab tom qab kis thoob qhov txhia chaw uas cov qauv kev tswj hwm thoob ntiaj teb tuaj yeem ua rau muaj kev sib raug zoo nrog cov thev naus laus zis digital txhawm rau ua kom muaj txiaj ntsig ntawm kev sim tshuaj xyuas thiab tso npe nkag. Cov thev naus laus zis tshiab xws li kua biopsy tau hloov zuj zus mus tas li, thiab cov kev nce qib no tam sim no tau nthuav tawm cov kev kuaj ntshav rau kev kuaj mob qog noj ntshav thaum ntxov tab sis nrog cov kev tswj hwm ntau ntxiv hauv kev ntsuam xyuas lawv qhov raug thiab siv tau. Txhawm rau ua tiav lub hom phiaj ntawm kev tswj hwm thoob ntiaj teb kev sib haum xeeb, kev sib koom tes ntawm ntau tus tswv cuab ntawm tsoomfwv, kev lag luam, kev kawm, kev txhawb nqa tus neeg mob thiab kev tshaj tawm yog qhov tseem ceeb, thiab qhov no yog qhov uas Cancer Moonshot tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev rhuav tshem cov silos thiab coj lub ntiaj teb ua ke. Cov kev siv zog no thaum kawg yuav txhim kho tus qauv kev saib xyuas rau cov neeg mob tsis yog hauv Asmeskas nkaus xwb tab sis kuj thoob ntiaj teb.

Hauv cov ntsiab lus, peb tau cog lus ntawm MSK txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhim kho thev naus laus zis tshiab thiab kev sib koom tes hauv kev sim tshuaj thoob ntiaj teb. Raws li Thawj Tswj Hwm Biden reignites Cancer Moonshot, peb sib cav hais tias mob qog noj ntshav tsis yog ib tug yeeb ncuab ntawm cov neeg Amelikas, tab sis tag nrho ntawm tib neeg, yog li nthuav tawm lub sijhawm tshwj xeeb rau Asmeskas kev coj noj coj ua thoob ntiaj teb. Peb tsis tuaj yeem tawm tsam mob qog noj ntshav ib leeg, tab sis los ntawm kev coj lub ntiaj teb ua ke los ntawm lub hli thoob ntiaj teb, peb tuaj yeem xaus mob qog noj ntshav raws li peb paub, hauv lub neej no ua ke.

-Nancy Y. Lee, MD, FASTRO, yog tus kws kho mob hluav taws xob hluav taws xob, Tus Thawj Coj ntawm Lub Taub Hau & Neck Radiation Oncology, Tus Thawj Saib Xyuas Kev Kho Mob Proton, thiab Tus Lwm Thawj Coj, Lub Tsev Haujlwm Saib Xyuas Hluav Taws Xob Oncology ntawm Memorial Sloan Kettering Cancer Center

-Lisa DeAngelis, MD, yog tus kws kho mob neuro-oncologist, Tus Kws Kho Mob-in-Chief thiab Chief Medical Officer; thiab Scott M. thiab Lisa G. Stuart Chair ntawm Memorial Sloan Kettering Cancer Center

-Bob T. Li, MD, PhD, MPH, yog kws kho mob oncologist, Tus Kws Kho Mob Ambassador rau Tuam Tshoj thiab Asia-Pacific; thiab Chief Scientific Officer, MSK Direct ntawm Memorial Sloan Kettering Cancer Center

Saib lwm cov posts:

Ntsib Tus Kws Lij Choj Ua Haujlwm Joe Biden's New Cancer Moonshot

"Vim li cas Cancer tsis tseem ceeb los kho sai dua Covid?": Cancer Moonshot Pathways

Incentivize Kev Tawm Tsam Tawm Tsam Mob Cancer Ua Rau Cov Me Nyuam: Cancer Moonshot Pathways

Breakthrough Barriers To Drive Progress: Cancer Moonshot Pathways

Biden Tsim nyog txais credit rau Kev Noj Qab Haus Huv: Cancer Moonshot Pathways

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